What is GLP-1 (glucagon-like peptide-1)?

Glucagon-like peptide-1 (GLP-1) is a hormone your gut releases after you eat. It signals the pancreas to release insulin when blood sugar rises, slows how quickly the stomach empties and acts on areas of the brain involved in appetite and fullness.

GLP-1 receptor agonists are medicines that mimic this hormone but last much longer in the body. Semaglutide (Ozempic, Wegovy, Rybelsus) and liraglutide (Saxenda, Victoza) act on the GLP-1 receptor. Tirzepatide (Mounjaro, Zepbound) acts on both the GLP-1 and GIP receptors, so it is often described as a dual agonist.

Most GLP-1 medicines start at a low dose that is increased in steps. Side effects, appetite and progress often change with each step and across the week between doses. A simple record of doses, symptoms and weight trend makes those patterns easier to see and to discuss with your prescriber.

GLP-1 medicines are prescription-only and are not suitable for everyone. Decisions about starting, changing or stopping a medicine belong with a qualified healthcare professional. Levli helps you record and understand your own journey; it does not give medical advice.